Specific cellular biomarkers for canine s breast cancer: literature review

Although there are many studies about the cellular biomarkers’ use in canine’s mammary cancer, the results are not to compare. This paper offers orientations about the most useful immunohistochemical markers, which can help to treat canine’s mammal tumors. The main biomarkers of the canines’ mammal epithelia and of the myoepithelial cells were reviewed and based on that, some orientations about immunoexpression of cadherin (E cadherin e P cadherin), proliferation marker (Ki-67), Human Epidermal Growth Factor (HER2 e HER3), estrogen and progesterone receptors were made. The incorporation of these information in future studies, either they be prospective or retrospective, will offer mechanisms that allow the direct comparison of the studies, and therefore will help to determine if the biomarkers have prognostic significance. The use of these biomarkers can help to point out the most adequate treatment to malignant canine’s mammal cancers.